Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination
MHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these molecules function by binding antigenic Caps peptides and presenting these peptides to antigen-specific CD4+ T cells.APCs continuously generate and degrade MHC-II molecules, and ubiquitination of MHC-II has recently been shown to be a key regulator of MHC-II ex